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Image Search Results
Journal: MedComm
Article Title: Design Strategies for Novel Lipid Nanoparticle for mRNA Vaccine and Therapeutics: Current Understandings and Future Perspectives
doi: 10.1002/mco2.70414
Figure Lengend Snippet: The optimization strategies for enhancing LNP targeting and endosomal escape are summarized as follows: panel (A) illustrates organ‐selective delivery profiles of various LNP formulations. Conventional ionizable lipids with p K a values ranging from 6.2 to 6.5 (e.g., DLin‐DMA, MC3, SM‐102, ALC‐0315, and 113‐O12B) exhibit liver tropism. Permanently ionizable lipids (e.g., DOTAP, DDAB, EPC, and 306‐N16B) favor lung targeting, while anionic lipids (e.g., 18PA, 14PA, and 18BMP) and polymer modifications (e.g., APEs and Pi‐A10) are associated with spleen accumulation. Panel (B) depicts key mechanisms of endosomal escape that enhance both CD4⁺ and CD8⁺ T cell responses. Strategies include conjugating LNPs with antibodies or PEI polymers, inhibiting the interaction between LNPs and ANXA6, and employing ionizable lipids with unsaturated hydrophobic tails, which significantly improve endosomal escape efficiency and thereby enhance antigen expression and immune activation. Panel (C) shows that LNPs can bind to ApoE, which facilitates recognition by LDLRs on hepatic endothelial cells, contributing to hepatic accumulation—a typical feature of traditional LNPs. Panel (D) outlines injection sites for different administration routes (intramuscular, subcutaneous, intravenous, and intradermal), which influence how LNP‐based vaccines enter the body and determine the type and strength of immune responses elicited (created in https://BioRender.com ).
Article Snippet:
Techniques: Polymer, Expressing, Activation Assay, Injection, Vaccines